Long acting antibiotic for use in cattle. Excede is also the first and only sustained-release antibiotic for use in horses. For use in lactating and non-lactating dairy cattle, beef cattle and calves for treatment of bovine respiratory disease (BRD) and for high risk cattle in the control of BRD associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni (Haemophilus somnus). Also for the treatment of foot rot associated with Fusobacterium necrophorum and Porphyromonas levii in beef and dairy cattle. Indicated for the treatment of acute metritis (0 to 10 days post-partum) associated with organisms susceptible to ceftiofur in lactating dairy cattle. For horses for the treatment of lower respiratory tract infections caused by susceptible strains of Streptococcus equi ssp. zooepidemicus, the most common pathogen isolated from equine respiratory infections.